Shape the future of lung health at Boehringer Ingelheim. Apply now with your research proposal and CV for this Postdoc opportunity in Pulmonary Lymphatic Dysfunction.

Lymphatic vessels are the unsung heroes of lung health - maintaining fluid balance and orchestrating immune responses. When they fail, the consequences ripple through chronic pulmonary diseases like pulmonary fibrosis (PF) and chronic obstructive pulmonary disease (COPD). We know they matter. What we don’t know is how and why. That’s where you come in.

The current scientific discussion evolves around the following topics:

Spatial and Temporal Remodeling: How do microvascular lymphatic networks adapt during disease initiation, progression, damage resolution and what governs the timing and localization of these changes?
Cellular Crosstalk: Which molecular mediators or physiological cues from the lymphatic microvasculature influence immune and structural cell behavior? (focus on epithelial, myeloid and stromal interactions)
Immune and Fluid Balance: How do lymphatics fine-tune the equilibrium between immune tolerance and inflammation? How the optimal interstitial fluids? How the resolution of inflammation and edema?
Phenotypic Signatures: What signals distinguish protective lymphatic adaptations from pathological ones? Do we understand lymphatic endotypes in lung diseases?
Causality: Are lymphatic abnormalities drivers of disease or early bystander adaptations to a disturbed lung microenvironment?
Disease Modeling and Biomarkers: Can we develop relevant complex in vitro models to study lymphatic dysfunction, and generate biomarkers

What potential solutions could be in scope?

The proposed human-derived model should enable the analysis of cellular crosstalk of lymphatic cells with epithelial, myeloid, and/or stromal cells, among others in PF and COPDendotypes. As such, it should support the identification of relevant phenotypic signatures, disease mechanisms, and biomarkers.
In addition, the project proposal should address at least one of the following scientific aspects with special emphasis on the gas-exchange unit:

Differences in lymphatic versus respiratory microvascular endothelial cell biology
Spatial and temporal regulation of lymphatic microvasculature
Functions in human health and disease (PF versus COPD)
Causality of lymphatic defects for pathogenesis (PF versus COPD)

What potential solutions would be out of scope?

Animal work
Human clinical trials
Pure in silico work
Adaptive immunity
Specific target proposals (we are looking for a broad and unbiased assessment of potential disease mechanisms)
Proposals that use the lymphatic system as a route for drug delivery

What are the requirements to participate in this call?

Please use ourPostDocgrant application template to provide a 4–5-pagenon-confidentialproposal (available for download on the following site). Pleasecomplement withyour CV, publication list, and recommendation letters.

If confidential data exists that would strengthen the proposal, pleaseindicatethat information is available to share under a Confidential Disclosure Agreement (CDA).If we find the non-confidential concept proposal sufficiently interesting, we will execute a CDA for confidential discussions.

Additional requirements:

PhD with a strong background in Molecular and Cell Biology.
Hands-onin vitroandex vivoexperience in human disease modeling using primary cells, tissue slices or iPSCs. FACS experience isa must.
Experience in generating multicellular models including media adaptations
Displayed examples of creativity that led to out-of-the-box scientific ideas and results.
Strong understanding of lymphatic biology and/or the pathways that drive the pathophysiology of lung diseases.
Trackrecordof independent research as exemplified through publications or patents.
Very goodoral communication and presentation skills as well as the ability to work in multidisciplinary teams in a matrix environment.
Fluent language skills in English are mandatory, German language skills is a plus.
Candidates with prior funding from other organizations will be preferred.

What will be the reward to the winner?

As a winner of this call, you will have the unique opportunity to pursue your own submitted research project as a fully resourced PostDoc project in the Immunology and Respiratory team at Boehringer Ingelheim at the Discovery Research site in Biberach/Riss, Germany. You will obtain a position for up to 3 years* with Boehringer Ingelinh within a cross-functional, international team of world-class scientists working on retinal diseases. The grant would also allow you to carry out parts of your planned experiments at your current home institution. (*The offered position initially covers a duration of 24 months with an option for extension by another 12 months.)

At Boehringer Ingelheim, you will have access to a fully equipped laboratory in a state-of-the-art research facility including access to all relevant tools and materials (e.g., human lung tissue, primary cell bank, organoid and MPS formats, small molecules, antibodies etc.) and technologies. Benefit from mentoring through our internal experts, have the chance to attend international conferences, and to publish your results in high-ranking journals. You will be part of the vibrant PostDoc community at Boehringer Ingelheim in Biberach with manifold opportunities for scientific, cross-functional exchanges for your personal development. You will have the opportunity to learn the process and challenges of drug discovery from the inside, including additional training and mentoring program.

In addition, benefit from the rich packages for employee benefit. Our most important asset in achieving our global vision is our people. We prioritize your growth, investing in our people through mentoring, coaching, skill-building, leadership development, and academic support. Our infrastructure promotes wellness with sports groups, health counseling, onsite medical services, and regular check-ups. Achieve work-life balance with flexible work hours, remote working, childcare support, counseling, and convenient amenities. We ensure financial health with employer loans, private insurances, access to discounts, and a company pension scheme. Benefit also from our excellent and healthy on-site catering and the opportunity to take away meals. We offer relocation support and interim accommodation to make joining us easy.

Working at Boehringer Ingelheim

Our purpose is to transform lives for generations. Therefore, we developed three key principles for our PostDoc program which are determining our plans and actions: Drive cutting-edge science, new concepts and technologies; enrich Boehringer Ingelheim’s innovation ecosystem with highly motivated, young fellows, who will help to build on science to develop new medicines; and train the next generation of leading scientists.
Our campus community culture is great for sharing ideas and makes it easy to access technologies, meet experts, and approach leaders of all levels. There’s a great spirit of freedom, fluidity, and fierce collaboration.
Interactions are sound and informal. It’s not particularly hierarchical, more team-based with a start-up attitude. We are always keen to help and speak up, open to positive change and new ideas that support our mission to improve lives.
Our Speak‑Up policy is an important part of our Code of Conduct. Only in this way we can continuously develop and improve as a company.
Our core values of empathy, respect, passion, and trust nurture a diverse, collaborative, open and inclusive environment which is key to innovation, value creation and sustainable growth. With the inclusion of various experiences, backgrounds, and characteristics, Boehringer Ingelheim creates an openness to different approaches, solutions, and perspectives, all contributing to create "Value through Innovation".

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Boehringer Ingelheim International GmbH

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PostDoc grant: Lymphatic dysfunction in chronic lung diseases

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