PhD position in human X chromosome regulation (m/f/x)

PhD position in human X chromosome regulation (m/f/x)

Ludwig-Maximilians-Universität München is a leading research university in Europe. LMU Munich conducts research of the highest international standards and offers excellent conditions for work in interdisciplinary networks.

Project location: Planegg, Germany. Position type: Part-time (65%), full project duration up to 5 years. Application deadline: .

Project Summary
This PhD project builds on an ongoing collaboration between groups in Mainz (Schweiger lab) and Basel (Keller Valsecchi lab) to investigate the molecular mechanisms controlling gene reactivation during development. Using human induced stem cell models with fluorescent reporters and high-throughput screening approaches, we aim to identify key regulatory factors and distinguish between gene-specific and global mechanisms governing X chromosome dynamics. This research aims to elucidate its contribution to female-biased disease across developmental trajectories.

Your Tasks And Responsibilities

• Design and execute imaging-based high-throughput screening experiments
• Develop, optimize cellular assays and CRISPR engineering using human iPS stem cell models and differentiation systems (2D or organoids)
• Perform functional validation of candidate hits using molecular biology techniques and smFISH
• Conduct multi-omics data integration across experimental platforms (e.g. NGS, imaging time lapse, particle tracing)
• Collaborate with interdisciplinary research teams and external partners in Basel (CH) and Mainz (DE)
• Mentor undergraduate and Master’s students in laboratory techniques
• Maintain detailed experimental records
• Effective time management with flexibility
• Present findings at lab meetings, conferences, and in peer‑reviewed publications

Your Qualifications

• Master’s degree (or comparable) in biology, biochemistry, molecular biology, biomedical sciences, medicine, or related natural science
• Strong sense of responsibility and teamwork
• Experience with cell culture is highly desirable; basic microscopy knowledge is an advantage
• Interest or experience at the interface between wet and dry lab is a plus
• Ability to work independently on scientific questions
• Good organizational skills, high work ethic, flexibility, curiosity, and passion for research

Benefits

• Exciting project in a modern laboratory with good infrastructure
• Mentorship for career development in academia and industry
• Support for relocation and onboarding for international PhD students
• Opportunities to participate in conferences and international collaborations
• Comprehensive LMU employee benefits and campus services
• Family-friendly provisions (e.g., campus kindergarten availability)
• Annual special payment, generous vacation, and pension scheme

Application Process

Please submit your complete application exclusively via our online application tool, including the following documents:

• Curriculum Vitae (PDF, max 2 pages, in English)
• Short description of research projects carried out during studies (approx. 300 words)
• Description of general research interests and career goals (approx. 200 words)
• What you find interesting about our research (approx. 200 words)
• Updated transcripts
• Contact details for at least two referees, including at least one direct supervisor (min. 6 months)

Applications will be considered by . For visa, housing, or health insurance inquiries, refer to LMU’s guidance resources.

Dietary/Accessibility/EEO information: LMU promotes diversity and equal opportunities in accordance with applicable policies.

Location: Martinsried, Bavaria, Germany

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