PhD position in human X chromosome regulation (m/f/x)

Overview

PhD position in human X chromosome regulation (m/f/x) at Ludwig-Maximilians-Universität München . Join to apply for the PhD position in human X chromosome regulation (m/f/x) role at LMU Munich. Start date: earliest convenience, 5 years max. Part-time 65% (TV-L E13) in Planegg.

About us

LMU Munich is a leading European research university known for excellence in research and teaching. The Biomedical Center (BMC) hosts the project, with proximity to the LMU University Hospital and other research institutes in Munich. Our work explores how alterations in chromatin regulation affect cellular organization and development, and how sex-specific differences relate to disease.

Project summary

This PhD project builds on collaboration between Mainz (Schweiger lab) and Basel (Keller Valsecchi lab) to investigate molecular mechanisms controlling gene reactivation during development. Using human iPS cell models with fluorescent reporters and high-throughput screening, we aim to identify key regulatory factors and distinguish gene-specific versus global mechanisms governing X chromosome dynamics, contributing to understanding female-biased diseases along development.

Your tasks and responsibilities

• Design and execute imaging-based high-throughput screening experiments
• Develop and optimize cellular assays and CRISPR engineering using human iPS stem cell models and differentiation systems (2D or organoids)
• Perform functional validation of candidate hits using molecular biology techniques and smFISH
• Conduct multi-omics data integration across experimental platforms (e.g., NGS, imaging time-lapse, particle tracing)
• Collaborate with interdisciplinary teams and external partners in Basel (CH) and Mainz (DE)
• Mentor undergraduate and Master’s students in laboratory techniques
• Maintain detailed experimental records
• Effective time management with flexibility
• Present findings at lab meetings, conferences, and in peer-reviewed publications

Your qualifications

• A Master’s degree (or comparable) in biology, biochemistry, molecular biology, biomedical sciences, medicine, or related natural sciences
• A high degree of responsibility and a proven record of teamwork
• Experience with cell culture techniques is desirable; knowledge of basic microscopy is a plus
• Interest or experience at the wet-dry lab interface is a plus
• Ability to work independently on scientific questions
• Strong organizational skills, work ethic, curiosity, and passion for research

Benefits

• Exciting project in a modern laboratory
• Creative working conditions in a top research environment
• Mentorship for career development (academic and industry)
• LMU Gateway support for international PhD students
• Opportunities to participate in international conferences and projects
• Involvement in BMC initiatives (Green Lab, public outreach, diversity and inclusion)
• Free parking and good public transport connections
• Family-friendly policies (on-campus kindergarten and emergency child care)
• LMU employee benefits (discounted fitness, cultural offers, public transport tickets, Jobbike, multiple canteens and cafés)
• Annual special payment, 30 days vacation and pension scheme

Application process and requirements

Please submit your complete application exclusively via our online application tool, including the following documents (in English where indicated):

• Curriculum Vitae (PDF, max 2 pages)
• Short description of research projects carried out during your studies (approx. 300 words) highlighting your contributions
• Description of your general research interests and career goals (approx. 200 words)
• What you find interesting about our research (approx. 200 words)
• Updated transcripts
• Contact details for at least two referees (including at least one direct supervisor who has worked with you for at least six months)

Deadline: . If applicable, AI-assisted editing should be transparently disclosed.

Questions about visa requirements, housing, or other practical matters may be directed to the LMU Gateway and Research in Bavaria resources. The BMC Code of Conduct supports diversity and equal opportunities.

Location and contact

Planegg, Bavaria, Germany

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