PostDoc in Molecular and Oncological Gynecology – Klinik für Frauenheilkunde und Geburtshilfe

Overview

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The Department of Molecular and Oncological Gynecology at the University Hospital Frankfurt invites applications for a Postdoctoral Researcher position at earliest possible time to join an innovative project investigating IVT-mRNA–based reactivation of tumor suppressor pathways in ovarian cancer. The position is located in a dynamic and collaborative research environment focusing on novel therapeutic strategies to overcome drug resistance in high-grade serous ovarian cancer. The project centers on the development and preclinical validation of next-generation lipid nanoparticle (LNP) carriers for IVT-mRNA delivery, both functionalized and non-functionalized with antibodies. These systems will be evaluated in patient-derived organoids and in vivo, using orthotopic and metastatic ovarian cancer mouse models, including PDX models, with the aim to improve targeted therapy and translational application.

The position is a limited appointment for a duration of two years.

Your Role

• Conduct in-depth research into the role of IVT-mRNA in the restoration of tumor suppressor genes in ovarian cancer and reversing therapy resistance.
• Perform mouse model experiments, including tumor induction, in vivo drug treatment, and assessment of tumor response using bioluminescence imaging.
• Development of patient-derived organoid cultures.
• Perform functional assays to assess cell viability, proliferation, apoptosis, and drug sensitivity in cancer models.
• Develop and implement innovative therapeutic strategies, including combination treatments with targeted IVT-mRNA and cisplatin.
• Collaborate with a multidisciplinary team of researchers and clinicians to interpret experimental results and drive the research forward.

Your skills and qualifications

• Ph.D. in Molecular Biology, Oncology, Pharmacy or a related field.
• Expertise in working with different mouse models, including tumor injection, intraperitoneal and intravenous treatment of mice, and in vivo treatments.
• Expertise in working with bioluminescence-based tumor imaging in vivo is highly desirable.
• FELASA Certificate is mandatory for the position.
• Knowledge of oncological therapeutic approaches, including combination therapies and targeted inhibition.
• Due to legal regulations, valid proof of measles immunity / measles vaccination is required.

What we offer

• In addition to an attractive salary based on a collective agreement with an annual special payment, you benefit from long-term security through company pension schemes.
• Internal and external training for your professional development.
• Benefit from our attractive health offers. We offer regular online and face-to-face courses on nutrition, relaxation, sports and exercise.
• Part-time employment is possible; we offer childcare in our daycare center (if you have any questions, please contact the family service), child care during holidays.
• Free public transport in all Hessen (Free State Ticket Hessen).
• Uniklinik-Campus, Mensa, Cafés.
• Insights: Instagram, YouTube, LinkedIn.

Application details

Contact: Priv. Doz. Dr. Mourad Sanhaji, Group Leader. Phone or Email: . Application Deadline: .

We welcome applications from candidates of all genders. Women are currently underrepresented in these positions at Universitätsmedizin Frankfurt. Therefore, applications from women are especially encouraged. Applicants with severe disabilities will be given preferential consideration in cases of equal personal and professional qualifications.

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