Senior Scientist - (RNA) Mass Spectrometry

Senior Scientist – (RNA) Mass Spectrometry

BioNTech SE in Martinsried, Bavaria, Germany is looking for an experienced Senior Scientist to design, develop, and implement innovative mass spectrometry assays for therapeutic messenger RNA (mRNA).

Responsibilities

• Lead development and optimization of high-resolution LC‑MS methods (Orbitrap, TIMS‑TOF) for intact mRNA, oligonucleotide fragments, nucleoside modifications, and related impurities.
• Design and execute sample‑preparation workflows (enzymatic digestion, chemical derivatization, solid‑phase extraction) to enable sensitive and robust mRNA analysis.
• Translate research‑grade methods into GMP‑compliant assays; draft qualification/validation plans and analytical reports for regulatory submissions (IND/CTA, BLA/MAA).
• Act as analytical SME providing expert knowledge for internal and external stakeholders; support regulatory filings and answer authority questions.
• Provide technical mentorship to junior scientists, research associates and interns.

Qualifications

• Ph.D. (or equivalent industrial experience) in Chemistry, Biochemistry, Pharmaceutical Sciences, Molecular Biology or related discipline.
• ≥ 10 years extensive experience in method development and data acquisition/analysis with high‑resolution mass spectrometers; at least 2 years focused on RNA, oligonucleotide or nucleic‑acid‑based therapeutics.
• Deep understanding of mRNA structure, chemical modifications, degradation pathways and formulation impact.
• Working knowledge of ICH, USP, Ph. Eur. and FDA/EMA expectations for analytical methods and GMP laboratories.
• Demonstrated ability to solve complex problems, manage projects from initiation to completion and collaborate effectively with cross‑functional, multicultural teams.
• Excellent written and verbal communication skills in English. Proficiency in German is desirable.

Benefits

• Flexible working hours and vacation account.
• Digital learning, performance‑ and talent development, leadership development and apprenticeship programmes.
• Employee voice on the table, inclusive culture, opportunities to shape impact and support your full potential.
• Company bike, mobility support (Job ticket, Deutschlandticket) and employer‑funded pension.
• Childcare support.

Application

Apply via our online form. For questions contact talent acquisition at +49 (0) 6131‑9084‑1291 (Mon‑Fri 12:00‑16:00 CET). Background checks will be conducted in accordance with applicable laws.

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