Master Thesis for Multiplex digital PCR using High-Density Microwell Arrays

Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Location Not Available

Stellenbeschreibung:

Vision to Products

Welcome to Hahn-Schickard: The research center for innovative microsystems technology. With a team of over 300 employees, we transform ideas into cross-industry solutions - from conception to production at four locations in Baden-Württemberg. At our Freiburg site, the emphasis is on developing analytical solutions in microsystems technology, particularly for point-of-care diagnostics.

For the area of Microfluidic Platforms in Freiburg , we offer from or later a

Master Thesis for Multiplex digital PCR using High-Density Microwell Arrays (m/f/x)

Aim of the thesis

Multiplexing in digital PCR is often limited by "partition-specific competition" in commercial devices (≈25,000 partitions), where co-encapsulated targets compete for reagents.
The goal of the thesis is to demonstrate how a LabDisk, with its high-density array of 250,000 microwells, eliminates this competition to ensure robust quantification of liquid biopsy targets like KRAS.

Your Tasks

Assay Development : Implement a multiplex Mediator Probe dPCR assay on the LabDisk.
Comparison : Validate LabDisk performance against commercial dPCR systems.
Data Analysis : Analyze high-density multiplex data.

Your profile

Studies : Biochemistry, Biotechnology, Molecular Biology, Medical Engineering, or a related STEM discipline.
Skills : Lab experience (pipetting/ PCR) and interest in bioanalytics.
Work Style : Independent and structured.
Language : Good English or German

Our offer to you

Flexible working hours
Insights into current digital PCR development for molecular diagnostics
Close supervision and the opportunity to contribute your own ideas
A young and dynamic team
An attractive workplace in a modern, excellently equipped research institute that is close to industry
Participation in first-class health programmes such as Hansefit
Subsidy for meals
Subsidies for public transport

Your Application

Mr. Dr. Peter Jülg will be pleased to answer any question you may have.

Peter.- / Tel.:

If you are interested, please send us your complete application documents (motivation letter/resume+CV/certificates/transcript of records), stating the reference number 26/3240/02 in a complete PDF document and naming the job portal here online via the application form.

The decision is made directly by the division.