PhD (m/f/d) Project P06 - RTG 3095 "Protective and pathogenic antibody responses at barrier organs"

University Hospital Schleswig-Holstein (UKSH) Kiel

Stellenbeschreibung:

PhD (m/f/d) Project P06 - RTG 3095 "Protective and pathogenic antibody responses at barrier organs"

Join to apply for the PhD (m/f/d) Project P06 – "Protective and pathogenic antibody responses at barrier organs" role at University Hospital Schleswig-Holstein (UKSH).

The DFG-funded Research Training Group (RTG) 3095 “Protective and pathogenic antibody responses at barrier organs” is a collaborative doctoral programme jointly organized by the University of Lübeck and Kiel University – two modern and research-intensive universities with strong profiles in medicine, molecular biology, and life sciences.

Immunological barrier organs such as the skin, intestine, and lungs are continuously exposed to commensal microorganisms, pathogens, and environmental allergens. Infections as well as allergic and autoinflammatory disorders at these mucosal interfaces are frequent and represent a significant burden to public health.

Antibody-mediated immune responses play a central role in maintaining homeostasis at these sites: they contribute to the control of pathogen invasion, the regulation of gut microbiota, and the initiation and modulation of allergic reactions, while also exerting regulatory functions that can down‑regulate inflammation.

The overarching goal of RTG 3095 is to elucidate the mechanisms by which B cell responses are initiated, maintained, and contribute to either immunoprotection or immunopathogenesis at these immunological barrier sites. To achieve this, the programme employs state‑of‑the‑art experimental approaches, including single‑cell sequencing, spatial transcriptomics, and advanced molecular and immunological techniques.

Doctoral researchers will benefit from a structured 4‑year training programme that integrates cutting‑edge research with comprehensive training opportunities.

In this framework, the subproject P06 “Lung‑resident B cells as producers of Immunoglobulin A”, led by Prof. Andreas Hutloff at the Institute for Immunology, Kiel University, is seeking a PhD Candidate to start on April 1, 2026 and will be limited until March 31, 2030 .

What we offer you:

Employment according to 65 % E 13 TV-L (German public sector pay scale) on a fixed‑term contract until March 31, 2030
Work in a strong, international, and interdisciplinary research team
Participation in the structured qualification programme of RTG 3095, including workshops, courses, and summer schools in state‑of‑the‑art immunology‑related research
A highly stimulating research environment with access to state‑of‑the‑art technologies such as single‑cell sequencing and spatial transcriptomics
Excellent opportunities for scientific networking and qualification in cutting‑edge immunological research

What you can expect:

Conducting a doctoral research project within P06, focusing on the question of why and how IgA+ B cells are only generated in the lung tissue but not the lung‑draining lymph node
To generate a single‑cell interactome of murine IgA and IgG B cells in the lung and lymph node
Active participation in the scientific programme of the RTG’s graduate training activities
Presentation and discussion of research findings within the research consortium

Your profile:

A Master’s degree (or equivalent) in the life sciences or a related discipline, fulfilling the formal requirements for enrolment as a doctoral candidate at the University of Lübeck
Excellent command of English
Experience with mouse models, flow cytometry, and molecular and cellular biology techniques, as well as knowledge of German, are advantageous
Motivation to apply bioinformatics approaches for the analysis of high‑throughput datasets (e.g., scRNA‑seq); experience with R or comparable statistical software is desirable
Strong motivation to contribute your own ideas to a dynamic, interactive research team and an independent, structured, and collaborative working style

Application:

A motivation letter (maximum one page), which also indicates if you are also interested in other projects within the RTG 3095 (a maximum of 3 projects)
A curriculum vitae (including a list of publications, if applicable)
Certificates and transcripts of your previous university degrees (BSc/MSc, including transcripts of records)
At least one letter of recommendation
Names and email addresses of two potential references

Selection process:

Application to this subproject of RTG 3095 is generally considered to be an application also to the other subprojects of RTG 3095. Separate application to another subproject is not required, but please indicate in your motivation letter your favoured RTG 3095 subprojects (see above, motivation letter).

Among the written applications, the most suitable candidates will be invited to a one‑day symposium, which will take place in January 2026 in Lübeck, Germany.

We look forward to receiving your application by , quoting reference number 27559 .