PhD-Position – Translational Tumor Immunology and Immunotherapy

Overview

The Goethe University Frankfurt is a leading research institution in immunological and molecular biology. In the research group “Translational Tumor Immunology and Immunotherapy” at the Department of Dermatology of Frankfurt University Hospital, a PhD position is available at the earliest possible date (three years, part time 65%).

Your role

The aim of this doctoral project is the identification and functional validation of HLA peptides, in particular neoantigens that arise from aberrant transcription and translation. The focus is assessment of immunogenicity using state‑of‑the‑art assays and imaging techniques to determine potential for cancer immunotherapy.

Responsibilities

• Perform and optimize T‑cell assays (e.g., ELISpot, intracellular cytokine staining, flow cytometry).
• Establish cytotoxicity assays to test antigen‑specific T‑cells against tumor cells.
• Apply live‑cell imaging to visualize interactions between T‑cells and tumor cells and antigen presentation.
• Present results at conferences and publish in peer‑reviewed journals.

Qualifications

• Master’s degree or equivalent in biology, biochemistry, molecular medicine or related field.
• Knowledge of cell culture and immunological laboratory techniques, especially T‑cell biology.
• Experience with flow cytometry (FACS) and/or microscopy is an advantage.
• High motivation, initiative, analytical thinking, and strong interest in translational cancer research.
• Very good written and spoken German and English skills.
• Valid proof of measles immunity or vaccination is required.

Benefits

• Access to state‑of‑the‑art technology and core facilities.
• Opportunities for further qualification and structured doctoral program.
• Attractive salary based on collective agreement with annual special payment and long‑term pension scheme.
• Internal and external training, childcare center, holiday care, campus cafeteria.
• Free public transport in Hessen and health offers fitness and nutrition courses.
• Available social media: Instagram, YouTube, LinkedIn.

Application

Contact: Prof. Dr. Bastian Schilling, Director of the Department of Dermatology
Phone:
Email:
Application Deadline:

We look forward to receiving your complete application, including cover letter, CV and references. We welcome applications from candidates of all genders. Women are strongly encouraged. Applicants with disabilities will receive preferential consideration in cases of equal qualifications.