PhD student - computational biology (m/f/d)

Stellenbeschreibung:

PhD Student (gn*) Experimental and Computational Life Sciences

Fixed term of 3 years | Full-time with 100% | Salary according to salary group 13 TV-L | Department of General Pediatrics | Job ID: 11760

We are UKM. We have a clear social mission and, with our focus on healthcare, research, and teaching, we bear a unique responsibility - ideally with you on board! The position is located in the research group of Dr. Alexander Busch (M.D.), and embedded in the DGF-funded Collaborative Research Centre 1748 ‘Principles of Reproduction’. The CRC 1748 involves scientists of the University of Muenster, the University Hospital, and the Max Planck Institute Muenster as well as scientists of the RWTH Aachen. Our central objective is to elucidate the genetic, molecular and cellular mechanisms governing the formation and function of the testis, production and function of sperm, fertilisation, as well as early embryonic development - in both health and disease. To this end, we combine interdisciplinary research in molecular, structural and cell biology as well as in physiology, biophysics, epi/genetics, (bio)informatics, and multimodal data analysis. The research group focuses on the mechanisms of Hypothalamic-Pituitary-Gonadal (HGP) axis regulation that governs human reproduction. The group investigates early activity periods of the HPG axis, i.e. mini-puberty and puberty. Combining clinical, large-scale genetic and single-nucleus approaches, the aim is to gain insight into reproductive disorders and fertility potential. The current project will use functional genomics to elucidate the molecular mechanisms underlying testosterone action.

Responsibilities

Implement laboratory and computational workflows for large-scale biological studies
Collect experimental and high-throughput data
Characterise molecular and cellular mechanisms underlying genetic variation
Participate in the Integrated Research Training Group ‘Reproduction.MS PhD-Training Centre in Translational Science’

REQUIREMENTS

Master’s degree in natural sciences, life sciences or similar
Strong interest in single-cell nucleus RNA-sequencing techniques/ Perturb-Seq/Crop-Seq
Willingness to learn computational biology/bioinformatics
High motivation for scientific work and willingness to contribute to an interdisciplinary team
Good English communication skills (spoken and written); German skills are advantageous

WE OFFER

Salary according to tariff agreement, extra annual payment, and company pension plan (VBL)
30 days of vacation per year, plus two additional days off on Christmas Eve and New Year's Eve
Competitive, interdisciplinary and international research environment with a track record of intense mutual collaboration
Structured PhD-training programme with a wide range of and professional development opportunities
A respectful and appreciative work environment within a diverse team
Support and advisory services for health and work-life balance
Additional benefits such as sports programs, job ticket, company events, cafeteria, and emergency childcare