Postdoc Molecular Biology Research in AML (m/f/d)

we are seeking a postdoctoral researcher starting March 2026 to join the research group of Dr. Michael Hoetker .

The Hoetker lab at the University Hospital Heidelberg focuses on the corruption of cellular identity in hematologic malignancies. In this project, we aim to decode epigenetic principles of acute myeloid leukemia (AML), understanding how the rewiring of chromatin landscapes contributes to the development and maintenance of malignant programs. The final aim of our studies is to translate our experimental findings into novel treatment strategies for patients at diagnosis and relapse.

The Department of Internal Medicine V of Heidelberg University Hospital is a leading center for research in Hematology and Oncology and provides numerous training opportunities with access to cutting‑edge techniques. The location of Heidelberg offers state‑of‑the‑art infrastructure in a highly collaborative environment (NCT, DKFZ and EMBL Heidelberg).

your tasks

• Investigate epigenetic mechanisms underlying AML by dissecting how altered chromatin states disrupt differentiation and maintain leukemia in a collaborative team of biologists and medical scientists
• Focus on chromatin biology and its interplay with transcriptional dysregulation in cancer
• Work with cell line systems, hiPSC‑based disease models, primary patient samples, and PDX models
• Plan and perform experiments within the framework of the scientific project plan, including epigenetic assays, gene expression analysis, cloning, lentiviral transductions, and genome editing
• Prepare and present project reports and contribute to publications

your profile

• MD or PhD in biology, biochemistry, molecular biology, or equivalent
• Strong expertise in molecular biology techniques including Western blotting, immunoprecipitations, epigenetic assays, cloning, cell culture, lentiviral transductions, and gene expression analysis
• Experience with at least two of the following: flow cytometry, microscopy, NGS techniques and analysis, CRISPR‑based epigenetic or genome editing
• Interest and ideally hands‑on experience in bioinformatics analysis of NGS data (ChIP‑seq, CUT&Tag, RNA‑seq, ATAC‑seq)
• Demonstrated ability in writing scientific reports and papers
• Proficiency with MS Office, graphic programs (Illustrator, ImageJ), statistical software (GraphPad Prism), and bioinformatics tools (R, BLAST)
• Fluent in both written and spoken English

About us

For further information please contact Dr. Michael Hoetker via

Interested?

Applications will be accepted direct online.

#J-18808-Ljbffr