Merck Life Science

Protein Engineer (all genders)

Stellenbeschreibung:

Work Your Magic with us! Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us. Job Summary The successful candidate will be responsible for the design, development, optimization, and scale-up of Protein A affinity ligands and associated purification processes for biopharmaceutical applications. Key Responsibilities Design and Engineering: Create and engineer Protein A variants with enhanced binding, stability, and selectivity characteristics.Project Leadership: Lead and execute projects aimed at developing and optimizing preparative chromatography processes, including resin screening, column packing, and process scale-up.Collaboration: Work with cross-functional teams in R&D, manufacturing, and quality to ensure smooth technology transfer and robust processes.Analytical Development: Develop and perform analytical assays to characterize Protein A ligands and assess purification performance.Documentation: Clearly document experimental work and contribute to technical reports, patent applications, and regulatory filings.Continuous Learning: Stay updated on advancements in protein engineering, affinity chromatography, and related bioprocessing technologies. Qualifications Education: PhD or MS in Biochemistry, Protein Engineering, Chemical Engineering, Biotechnology, or a related field.Experience: Minimum of 10 years of hands-on experience in protein engineering and preparative chromatography, particularly with Protein A affinity systems.Technical Skills: Proficient in molecular biology techniques, protein expression and purification, and chromatographic method development.Analytical Skills: Strong analytical and problem-solving skills with experience in data analysis and interpretation.Communication: Excellent communication and teamwork abilities. Preferred Experience Experience in the scale-up and manufacturing of chromatography processes.Familiarity with regulatory requirements for biopharmaceutical manufacturing.Knowledge of downstream processing for monoclonal antibodies. This role is vital for advancing the development of purification processes essential for biopharmaceutical applications. What we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress! Apply now and become a part of a team that is dedicated to Sparking Discovery and Elevating Humanity!
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Stelleninformationen

  • Veröffentlichungsdatum:

    12 Nov 2025
  • Standort:

    Darmstadt
  • Typ:

    Vollzeit
  • Arbeitsmodell:

    Vor Ort
  • Kategorie:

  • Erfahrung:

    Erfahren
  • Arbeitsverhältnis:

    Angestellt

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