PhD Student Biology - Hematology (m/f/d)

The Department of Pediatric Oncology, Hematology and Clinical Immunology at the University Hospital Düsseldorf (UKD) is offering a PhD student position within our research group, which is dedicated to developing novel, individualized drug targets and therapies for high-risk childhood leukemia. While event-free survival for childhood Acute Lymphoblastic Leukemia (ALL) has improved to over 80% in the last decade, specific high-risk subgroups still face a dismal prognosis. To address this, we are investigating novel precision compounds and synergistic drug combinations, including clinically used drugs, to overcome drug resistance and target oncogene stabilization (Vogt et al. Cell Death Dis 14, )).
We are looking for a highly motivated and team-oriented
PhD Student (m/f/d)
to join our research group on 'Novel Targeted Therapies for Resistant Childhood Acute Leukemia' .
Activities And Responsibilities

• Planning and execution of molecular biological experiments using leukemia cell lines and primary patient-derived cells
• Performing advanced Protein Analysis techniques (Western Blotting, Flow Cytometry)
• RNA Analysis (qPCR, RNA sequencing)
• Drug Screening of therapeutic compounds to identify novel vulnerabilities
• Genetic Engineering: Utilizing cutting-edge technologies, including CRISPR/Cas9 genome editing, viral transduction, and nucleofection
• In Vivo Research: Designing and performing experiments with mouse models to study leukemia progression and treatment response
  

• A Master’s degree in biology or a related field
• Proven experience with in vivo (mouse) models and a FELASA B certification are required
• Extensive hands-on experience in laboratory work, utilizing a broad spectrum of methods in biochemistry, molecular biology, and cell biology
• Strong analytical skills with the ability to design experiments, interpret complex data sets, and work independently
  

• A highly motivated and communicative atmosphere within a successful translational research group, offering access to core facilities and opportunities to present your research at international conferences.
• A thorough introduction to the skills needed, accompanied by supervision and guidance
• An initial 2-year contract with the possibility of an extension for the duration of the PhD
• Salary according to the German public service scale (TV-L E13, 65%)