Postdoc - Molecular Biology Research in MLLr acute leukemia (f/m/d)

sought at the next possible date at the Department of Hematology, Oncology, and Rheumatology in the research group of Prof. Carsten Müller-Tidow .

The Department of Internal Medicine V of Heidelberg University Hospital is a leading center for research in Hematology and Oncology. The location of Heidelberg offers state-of-the-art infrastructure in a highly collaborative environment (NCT, DKFZ and EMBL Heidelberg).

The work of our research group ( focuses on stem cells and therapy resistance. We aim to understand how epigenetic dysregulation participates in the pathogenesis and chemoresistance of AML. To follow this question a broad number of in-vitro- and in-vivo-models are investigated. The final aim of our studies is to translate the experimental findings into novel treatment strategies for AML patients at diagnosis and relapse.

Your Tasks

• The postdoctoral fellow will work in a team of enthusiastic biologists and medical scientists with the aim to identify networks in the regulation of human leukemia stem cell activity and to understand the mechanisms of developing and overcoming therapy resistance. MLLr acute leukemia is the target in this project
• Focus on epitranscriptomic modifications and gene expression with regulation of translation in cancer
• Multi-Omics single cell sequencing approaches to characterize therapy resistance
• Responsible planning and performing of experiments in the framework of the scientific project plan
• Preparation and presentation of project reports and publications

Your Profile

• PhD in biology, biochemistry or equivalent
• Proven experience in research of MLLr acute leukemia
• Broad expertise in basic cell-molecular and biochemical techniques (Western blotting, immunoprecipitations, ChIP, gene expression analysis, cloning, cell culture, lentiviral transductions, flow cytometry, microscopy etc.)
• Experience and skills in Next-Generation-Sequencing, CRISPR/CAS9, shRNA-mediated knock down and genome editing techniques
• Experience in writing scientific reports and papers
• Very good knowledge of and experience with MS office, graphic programs, statistical software, bioinformatics tools and online tools (e.g. Illustrator, Lightroom, GraphPadPrism, R, BLAST)
• Fluent both in written and spoken English language

About us

For further information please contact Annette Becker via e-mail.

Interested?

Applications will be accepted until direct online.