Principal Scientist

We are seeking an experienced Principal Scientist in Pharmacology to provide scientific leadership across preclinical pharmacology activities within a growing biotech environment. This role sits at the core of the preclinical development organisation and plays a key role in advancing small-molecule programmes from early discovery through IND-enabling studies, supporting progression toward first-in-human trials. Key Responsibilities

Lead and shape preclinical pharmacology strategy across multiple discovery and development programmes Act as the pharmacology lead on project teams, providing clear scientific guidance on mechanism, efficacy, and translational relevance Design, oversee, and interpret in vitro and in vivo pharmacology studies to support candidate selection and IND-enabling development Integrate pharmacology data with DMPK, toxicology, and biomarker strategies to inform dose selection and clinical translation Communicate complex pharmacology data clearly to project teams and senior leadership Manage CROs and external partners, ensuring studies are delivered to high scientific and quality standards Contribute to the development and mentoring of internal pharmacology capability as the organisation grows Candidate Profile

PhD (or equivalent) in Pharmacology, Biology, or a related discipline Significant industry experience in preclinical pharmacology within biotech, pharma, or CRO settings Proven track record of advancing small-molecule programmes through lead optimisation and IND-enabling development Strong understanding of translational pharmacology and principles supporting first-in-human dose selection Confidence in making and defending scientific decisions in a fast-paced, collaborative environment

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