Senior Clinical Project Manager

Clinical Project Manager - RWE Vaccines study - Strong budget management experience

Upsilon Global are seeking an experienced Project Manager for a pivotal ongoing RSV vaccine effectiveness study. This is a crucial project and one that requires a PM with strong study budget experience, organisational skills and experience in reigniting under-performing projects.

You'll be working closely with the global head of operations and local/regional teams to mitigate existing issues to success as well as the commercial/finance team to manage study budget and reporting effectively.

This is a fantastic opportunity for someone with strong leadership and organisational skills to have a major impact in identifying issues and and proactively addressing them to deliver successful change.

Key information: Position:

Clinical Project Manager / Sr Clinical Project Manager Employment:

Freelance FTE:

0.5-0.6 FTE initially, rising to 0.8-0.9 FTE from August/September in line ith RSV season Indication:

RSV Vaccine Start Date:

March2026 Duration:

Initial 12 month contract Location:

Remote/fully homebased

Key duties: Helping/training the internal PMs on; Project expectations Risk management/awareness (forward thinking/risk awareness/quality by design) Project finances (margins, burn rates, costs, internal fixed costs vs PTCs and general study budget management) ICH-GCP guidelines (focus on E6, R3)

Background and experience: Strong study budget experience including; Internal fixed fee management – burn and scope management PT management (sites, vendors, other) Ability to understand (not necessarily update) study budget tool algorithms and mapping Site cost management – planned vs actuals; accruals, invoiced, paid, reconciliation with study budget, etc Change Order management (including directing budget team on what to update and why); Negotiations with clients Scope management Process alignment Experience with budget reconciliations (eg planned vs actual + expected units/spend) Strong excel skills Experience working with commercial/budgets team and ability to take full accountability for the budget management and steps within, and not rely on other departments to drive the process.

Strong organisational skills Ability to proactively identify gaps in processes, drive process improvements, expand on best practices, etc. Ability/experience to proactively create study tools and processes if needed and not currently within our scope (nothing complex, but can not rely 100% on internal solutions) Must have a ‘let’s make it happen’ attitude

Strong leadership skills PMs to be fully accountable for the delivery and quality of their study. Must be a "driver", autonomous and a leader Experience with taking on an underperforming project and mitigating existing issues to success

Experience Vaccine effectiveness, RWE experience essential Seasonal ID experience (RSV beneficial) Small-mid size CRO experience Experience with working on a multi-centre study in Germany (eg awareness of German approval process) This role would be well suited to an experienced PM with a background in training and development of junior colleagues.

For more details please apply or contract to register your interest.