RBW are working in partnership with a global organisation that are searching for an experienced DMPK Lead to implement strategy across all DMPK disciplines including PK/PD, ADME, Biotransformation etc. from early discovery through to clinical development.

Responsibilities:

Lead the nonclinical DMPK strategy and design the appropriate studies to fulfil regulatory requirements

Have an expert understanding of the different approaches related to nonclinical pharmacokinetics

Apply understanding of physical properties, DMPK and enzymology to contribute to the design of new compounds

Work with colleagues globally to resolve project-related ADME challenges

Author high quality regulatory documents including INDs, CTAs and NDA filings

Experience:

Educated to PhD in a scientific related discipline

Minimum 5 years industry experience contributing to drug discovery projects with a track record of moving small molecules from target validation to first in humans

Strong background in the area of DMPK/ADME across discovery and development

Good understanding of PKPD and PBPK modelling

Proven skills for in-depth mechanistic understanding of DMPK-related issues and of the impact and value of translation to humans

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RBW Consulting