Bioinformatician (f/m/d) for Epigenetic Networks in Aging and Cancer

The Helmholtz Institute for Biomedical Engineering -

Bioinformatician (f/m/d) for Epigenetic Networks in Aging and Cancer

• postdoctoral position

Operational area: Helmholtz Institute for Biomedical Engineering -Institute for Stem Cell Biology-

Working hours: 100% of the collectively agreed full-time working hours (currently 38.5 hours per week)

Duration/Term of employment: Initially limited to 2,5 years.

Start date:

Remuneration/Rates:   EG 13 (TV-L)

Within the project “Transform-Me” (supported by the Else Kröner-Fresenius Stiftung), we are investigating how epigenetic changes, particularly DNA methylation patterns, are coordinated across the genome. We anticipate these modifications are coherently modified in trans within epigenetic networks. We want to identify modules and hubs that are co-regulated in aging, development, and particularly in malignant transformation. Furthermore, we aim to modulate these epigenetic networks by epigenetic editing. We are looking for a bioinformatician with a strong background in epigenetic characterization of cell preparations with focus on DNA methylation. We are integrating own and public EPIC Illumina Bead Chip datasets, RNA-seq, ATAC-seq, ChIP-seq, nanopore, and single cell DNAm sequencing datasets.

You can find further information on our research group under:

Your tasks:

• Integrative analysis of many epigenetic datasets, particularly DNAm profiles from public repositories
• Coregulation and network analysis
• Machine learning approaches predicting epigenetic patterns
• Analysis and integration of chromatin accessibility and histone modifications
• Analysis of single cell DNAm datasets
• Design and analysis of epigenetic editing experiments
• Scientific publication of the results

Your profile:

• Master’s degree in either Biology, Bioinformatics, or comparable degrees in Natural Sciences
• A successful PhD with bioinformatics on epigenetics or stem cell research
• Bioinformatic skills for DNA methylation analysis
• programming languages R and optionally perl or python
• Knowledge in cancer and aging research
• Willingness to contribute to different projects within our team
• Able to communicate clearly in English and willing to work in an international team
• Relevant scientific publications

Why you should choose us?

We offer…

• We provide a highly interactive and well-equipped environment, in an international team, with excellent partners
• The research topic is very timely, clinically relevant, and challenging
• 30 days of vacation per year for full-time employment