2 PhD students (Biology, Biochemistry, Molecular Medicine) (m/f/d)

The Institute for Immunodeficiency of the University Hospital Freiburg (AG Prof. Stephan Ehl) is searching for

2 PhD students (Biology, Biochemistry, Molecular Medicine) (m/f/d)

We study T cell immunity starting from patients with genetic defects of the immune system who offer a unique opportunity to understand human immunology. Such patients present with severe or unusual infections and/or with manifestations of impaired immune regulation such as autoimmunity, lymphoproliferation or autoinflammation. We focus on defects of T cell activation, effector function and homeostasis ( We want to understand the cellular and molecular basis of these immunodeficiencies, discover and characterize novel genetic defects and apply this knowledge to improve diagnostics and therapy (e.g. Grün JACI 2025, Maccari JExpMed 2021, Gross JACI 2021, Kury EBiomedicine 2020).

You will work in a team with experienced basic and physician scientists in projects of T cell immunology. Work with patient cohorts and collaboration with our Advanced Diagnostic Unit will offer interesting insights into the clinical implications of immunological research. Some projects are complemented by studies in corresponding mouse models. A growing number of methods are applied including (spectral) flow cytometry, CyTOF, (sc)RNAseq, TCR deep sequencing, qPCR, cloning, retroviral transductions and microscopy. Knowledge in immunology, molecular biology and interest in bioinformatics is advantageous.

We look forward to your electronic application at:

Further information also via:

0761/

General information: Salary is assigned according to a pay scale. Unless prevented by operational or legal reasons, full-time positions are generally open to those wishing to job share.Where two candidates are equally suitable for a post, severely disabled candidates are given priority. Employment decisions are made by the Personnel Department.