Master thesis (f/m/x) – Molecular mechanisms behind the neurodevelopmental disorder PURA syndrome

Helmholtz Zentrum MünchenOberschleißheim

Stellenbeschreibung:

Master thesis (f/m/x) – Molecular mechanisms behind the neurodevelopmental disorder PURA syndrome

Full time
39 hrs./week

Neuherberg near Munich

At Helmholtz Munich, we develop groundbreaking solutions for a healthier society in a rapidly changing world. We believe that diverse perspectives drive innovation. Through strong partnerships, we accelerate the transfer of new ideas from the lab to real-life applications, improving lives.

We at the Institute of Structural Biology (STB) at Helmholtz Munich study the structure and function of the PURA protein. Our overall goal is to understand PURA’s cellular functions and the molecular consequences of a PURA deficiency in PURA syndrome patients. Therefore, we use genetically modified immortalized cell lines and patient-specific induced pluripotent stem cells (iPSCs). High-throughput techniques in these cells already gave us first ideas about PURA’s interactome and in which pathways PURA may play a role. These data need further validation to identify specific molecular mechanisms that cause the severe disorder. Ultimately, we want to provide information that can lead to the development of treatment strategies for PURA syndrome patients.

Interested? Join us on this crucial and challenging task for your master thesis or contact us if you want to be part of this as an intern .

For further information on the PURA Syndrome visit: and check out our lab:

Your tasks

Actively contribute to an ongoing research project by culturing and maintaining human neural stem cells and iPSCs
Differentiate pluripotent stem cells into neural cells
Plan, execute, analyze, and interpret experiments to support research activities
Apply gene editing strategies
Contribute to high-throughput experiments

Your profile

Master’s student in Life Sciences (e.g. Biology, Biochemistry, Biotechnology, Molecular Biology or related fields)
Solid theoretical background in cell biology and molecular biology; prior hands‑on experience in cell culture or gene editing is advantageous
Strong interest in experimental research and motivation to actively contribute to an ongoing scientific project
Good written and spoken English skills

This position has a fixed term of6 months.

Managing Director Mike Frieser:

We believe that diversity is the key to groundbreaking research and innovative solutions. Our flexible working models and remote options create a supportive environment for balancing work and family life. For us, contributing to a healthier society in such an inspiring workplace is truly meaningful.

Get to know us

Interested in applying?

If you have any questions, feel free to contact Silvia Marcato, , who will be happy to help.

Our recruiting is decentralized - your application will be reviewed directly by the specialist department in which you could work in the future.

More information about our application process

Please send your application only via our online application tool and with the following documents:

CV
Cover letter

If you have obtained a university degree abroad, we will require further documents from you regarding the comparability of your degree. Please request the Statement of Comparability for Foreign Higher Education Qualifications as early as possible.

We are committed to promoting a culture of diversity and welcome applications from talented people regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical abilities, religion or age. Qualified applicants with physical disabilities will be given preference.

Learn more about diversity at Helmholtz Munich