Master’s Thesis in Cardiac Gene Therapy and Translational Genome Editing

Master's Thesis – AAV‑based Genome Editing in Cardiac Models

Conducted in the Kupatt Laboratory (TUM Rechts der Isar), this 6–12‑month thesis focuses on AAV‑mediated CRISPR, base, and prime editing in mouse and porcine cardiac models. The project aims to systematically evaluate how delivery strategy, developmental stage, and model system influence genome‑editing efficiency and therapeutic potential in the heart.

Responsibilities

• Perform molecular cloning and AAV‑related experiments.
• Work with mouse and/or porcine models of cardiac gene therapy.
• Analyze genome‑editing outcomes at DNA and RNA levels.
• Interpret results in a physiological and translational context.
• Contribute to figures, datasets, and scientific manuscripts.

Candidate Profile

• Background in molecular biology, biotechnology, biomedicine, or life sciences.
• Strong interest in gene therapy, genome editing, or cardiovascular research.
• Basic laboratory experience in molecular biology techniques.
• Willingness to work with animal models (training provided).
• Prior experience with AAV, CRISPR, sequencing, or histology is an advantage but not required.

Benefits

• Hands‑on training in state‑of‑the‑art cardiac gene therapy and genome editing.
• Exposure to both small‑ and large‑animal translational research.
• Close supervision and mentoring.
• Opportunity to contribute to high‑impact scientific publications.
• A collaborative and international research environment.

Supervision: Prof. Dr. med. Christian Kupatt, with close supervision by Dr. Vijayanand Rajendran and Dr. Tarik Bozoglu.

How to Apply
Send your CV and a brief introductory email outlining your background and availability to .

Contact
Dr. Vijayanand Rajendran

Klinik und Poliklinik für Innere Medizin I – Kardiologie
TUM Klinikum Rechts der Isar
Ismaninger Straße 22, 81675 München

Disabled persons are welcome to apply; disabled applicants will receive preference in case of generally equivalent suitability, aptitude, and professional performance.