PhD Position (m/f/d) in Ion Channel Physiology and Retinal Research

Stellenbeschreibung:

PhD Position (m/f/d) in Ion Channel Physiology and Retinal Research – Immediate start – Full‑time – Jena – Compensation based on TV‑L** – Fixed‑term contract for 2 years, with option to extend – Scholarship of 1,500 euros.

This project centers on cyclic nucleotide‑gated (CNG) channels in retinal photoreceptors. These channels are essential for visual signal transduction and play a pivotal role in disorders such as retinitis pigmentosa (RP) and achromatopsia (ACHM). The aim is to develop selective pharmacological strategies targeting rod‑ and cone‑specific CNG channel isoforms and to elucidate the underlying molecular mechanisms. The PhD position is funded through a PRO RETINA Foundation fellowship.

Your Responsibilities

Perform electrophysiological recordings (e.g., patch‑clamp) on heterologously expressed channels in Xenopus oocytes; analyze novel cGMP analogs and allosteric modulators.
Investigate ligand binding to retinal CNG channels to clarify the mechanisms driving isoform‑specific activation and regulation.
Integrate experimental findings with computational approaches (molecular docking, molecular dynamics simulations); conduct systematic analysis and interpretation of electrophysiological and molecular data.
Prepare manuscripts and present results at scientific conferences.

Your Profile

Master’s degree in Biology, Biochemistry, Pharmacy, Biophysics, or a related discipline.
Preferably initial experience with electrophysiological techniques (e.g., patch‑clamp), cell/molecular biology methods, or molecular docking and MD simulations.
Basic knowledge of ion channel physiology is an advantage.
Highly motivated, well‑organized, and curious mindset.
Strong communication and teamwork skills.
Excellent written and spoken English skills; good working knowledge of German is an advantage.
Solid computer skills.
Willingness to travel for project‑related meetings and conferences.