Postdoctoral position: Gene expression regulation (f/m/x) Wiss2603-13 | Institute for Genetics/[...]

Postdoctoral position: Gene expression regulation (f/m/x) Wiss | Institute for Genetics/CECAD Cluster of Excellence

The Uhlirova lab ( explores how stress‑inducible signaling pathways control gene expression and influence tissue homeostasis and longevity. To tackle these questions, we combine the power of functional genetics in Drosophila and mouse models with cutting‑edge molecular and cell biology, multi‑omics approaches, advanced microscopy, and bioinformatics. We are looking for a highly motivated and curious postdoctoral candidate (f/m/x) to join our dynamic team. You will have the opportunity to lead your own project, contribute to collaborative research, and develop skills at the interface of genetics, molecular and cell biology, and systems‑level analysis.

YOUR TASKS

• To study the crosstalk between transcription and pre‑mRNA splicing under physiological, stress, and disease conditions
• To investigate mechanisms underlying spliceosome assembly and functional plasticity
• To uncover what renders different transcripts, cells, and tissues sensitive to aberrant splicing
• To elucidate how spliceosome malfunction impacts genome stability and contributes to loss of tissue homeostasis, premature ageing and diseases

YOUR PROFILE

• Completed doctoral degree in Biology / Biochemistry / Biophysics or related areas of Life Sciences
• Motivation, curiosity and creativity, and a strong ability to solve problems through critical analytical thinking
• Strong background in genetics, molecular and cell biology is essential
• Proven ability to carry out an independent scientific project and unwavering commitment to high‑quality research
• Hands‑on experience in working with model organisms, preferably Drosophila and/or mouse and in vitro systems
• Excellent communication skills, fluency in spoken and written English
• Strong commitment to collaboration and teamwork

DESIRED ASSETS

• Experience in multi‑omics research projects and data analysis
• Familiarity with iPSC and / or organoid models
• Expertise in computational modelling of protein‑RNA and protein‑protein interactions
• Experience in quantitative image analysis and attention to detail
• Strong organisational and thorough documentation skills

WE OFFER

• Interactive and international team with access to the state‑of‑the‑art research facilities
• A diverse working environment with equal opportunities
• Support in balancing work and family life
• Extensive advanced training opportunities
• Occupational health management offers
• Flexible working time models

The position is available from 1 October 2026 on a full‑time basis (39,83 hours per week). It is limited for two years until 30 September 2028. If the applicant meets the relevant wage requirements and personal qualifications, the salary is based on remuneration group 13 TV‑L of the pay scale for the German public sector.

The University of Cologne promotes equal opportunities and diversity. Women will be considered preferentially in accordance with the Equal Opportunities Act of North Rhine‑Westphalia (Landesgleichstellungsgesetz – LGG NRW). We also expressly welcome applications from all suitable candidates regardless of their gender, nationality, ethnic and social origin, religion, disability, age, sexual orientation and identity.

For further inquiries, please contact Professor Mirka Uhlirova / Dr Esther Wollert at