The Downstream Process Specialist is responsible for the purification of high-capacity adenoviral (HCAd) vectors for pre-clinical development. In this role you will execute downstream purification batches using our platform process and support experiments to characterize and optimize the process. You will work hands‑on with chromatography, tangential flow filtration (TFF), and filtration systems, while helping to build an efficient lab environment with strong operational practices.

Key responsibilities

Downstream processing operations
Prepare and execute downstream purification batches for pre-clinical HCAd vector production.
Perform core unit operations including chromatography, tangential flow filtration (TFF) and filtration.
Prepare buffers, manifolds, consumables, and equipment required for batch execution.
Ensure activities are performed according to process instructions and production schedules.
Perform experiments to characterize, troubleshoot, and optimize the downstream process.
Document experimental protocols and record data accurately.
Share results and technical observations with the team.
Laboratory and operational readiness
Contribute to lab set‑up, organization, and efficient operational practices.
Keep equipment in a ready‑to‑use state, including routine checks and cleaning.
Manage inventories of consumables, reagents, and samples.
Ensure materials are available to support planned production and development activities.
Maintain a clean, safe, and organized working environment.
Troubleshoot and report unexpected events and issues promptly.
Documentation & Quality practices
Complete batch records, logbooks, inventory records, and experimental documentation accurately and on time.
Support the development and improvement of SOPs, work instructions, and documentation systems.
Follow internal procedures and good documentation practices consistently.

Qualifications

Bachelor’s degree in biotechnology, biochemistry, biology, or a related field with 5+ years of relevant experience or master’s degree with 2+ years of relevant experience.
Previous experience in the bioprocessing industry, ideally in viral vector production, is highly preferred.
Hands‑on experience with chromatography systems such as ÄKTA and UNICORN™ software is required.
Experience with TFF systems such as KrosFlo® and/or ÄKTA flux.
Experience with filtration operations, buffer preparation, and routine lab activities.
Strong organizational skills, proactivity and troubleshooting capability.
Reliable and able to work in a fast‑paced, evolving R&D environment.
Good documentation practices and communication skills.
Excellent oral and written English communication skills. German is a plus.
Work with the latest technologies in a modern, state‑of‑the‑art working environment.
Full‑time employment with long‑term career prospects.
Attractive employee benefits and comprehensive health & wellness program.
Complimentary snacks and beverages.
Regular team and company events, including summer parties and Christmas celebrations.
Relocation support, including assistance with finding accommodation.

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Pacira Germany