DMPK Project Lead

RBW are working in partnership with a global organisation that are searching for an experienced DMPK Lead to implement strategy across all DMPK disciplines including PK/PD, ADME, Biotransformation etc. from early discovery through to clinical development.

Responsibilities:

• Lead the nonclinical DMPK strategy and design the appropriate studies to fulfil regulatory requirements


• Have an expert understanding of the different approaches related to nonclinical pharmacokinetics


• Apply understanding of physical properties, DMPK and enzymology to contribute to the design of new compounds


• Work with colleagues globally to resolve project-related ADME challenges


• Author high quality regulatory documents including INDs, CTAs and NDA filings

Experience:

• Educated to PhD in a scientific related discipline


• Minimum 5 years industry experience contributing to drug discovery projects with a track record of moving small molecules from target validation to first in humans


• Strong background in the area of DMPK/ADME across discovery and development


• Good understanding of PKPD and PBPK modelling


• Proven skills for in-depth mechanistic understanding of DMPK-related issues and of the impact and value of translation to humans